The supplement designed for life on GLP-1.
GLP-1 medications suppress appetite significantly. That is the point. But eating less means absorbing less — and the body's demands do not reduce alongside intake. CHAPTER. is the only supplement formulated specifically around that gap.
How GLP-1 works.
GLP-1 is a hormone the gut produces naturally in response to eating. It signals the pancreas to release insulin, slows the passage of food through the stomach, and tells the brain the body is full. Under normal conditions the effect is brief. The hormone degrades quickly and appetite returns.
GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) are synthetic compounds that mimic this hormone but resist degradation. They bind to receptors in the gut, pancreas, and brain, sustaining an elevated fullness signal continuously. Most people on GLP-1 therapy reduce their food intake by 30 to 60 percent.
The medication does exactly what it is designed to do. But appetite suppression is not selective. When food intake falls that significantly, so does everything food carries: vitamins, minerals, electrolytes, protein. The raw materials the body uses to maintain muscle, regulate digestion, and sustain energy.
That is the mechanism. And it is also the gap. CHAPTER. was formulated specifically to fill it.
How GLP-1 works.
GLP-1 is a hormone the gut produces naturally in response to eating. It signals the pancreas to release insulin, slows the passage of food through the stomach, and tells the brain the body is full. Under normal conditions the effect is brief. The hormone degrades quickly and appetite returns.
GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) are synthetic compounds that mimic this hormone but resist degradation. They bind to receptors in the gut, pancreas, and brain, sustaining an elevated fullness signal continuously. Most people on GLP-1 therapy reduce their food intake by 30 to 60 percent.
The medication does exactly what it is designed to do. But appetite suppression is not selective. When food intake falls that significantly, so does everything food carries: vitamins, minerals, electrolytes, protein. The raw materials the body uses to maintain muscle, regulate digestion, and sustain energy.
That is the mechanism. And it is also the gap. CHAPTER. was formulated specifically to fill it.
Clinical ingredient evidence
The research behind
every ingredient.
The formula contains 26 individually selected ingredients. Below are five examples — one for each challenge GLP-1 creates — showing the calibre of evidence behind every formulation decision.
640+
Published studies
26
Active ingredients
5
GLP-1 challenges addressed
Digestion
100+
Published studies
Sunfiber® PHGG 500mg
Partially hydrolysed guar gum with one of the largest evidence bases of any dietary fibre. Published studies confirm it supports gut regularity and microbiome balance without causing gas or bloating.
J Nutr Sci, Nutrition Research
Cognition
20+
Published studies
Citicoline 200mg
Double-blind studies in healthy adults show meaningful improvements in memory, attention and mental focus. One of the most rigorously studied cognitive support compounds available.
Nutrition, J Alzheimer's Dis
Muscle loss
500+
Published studies
Creatine Monohydrate 3,000mg
Rapid weight loss does not distinguish between fat and lean tissue. Creatine monohydrate has the most extensive evidence base of any single nutrient for preserving lean tissue and maintaining physical function during significant caloric restriction. Multiple independent meta-analyses confirm efficacy at 3g daily.
Multiple meta-analyses, ISSN Position Stand
Hydration
10+
Published studies
Magnesium Bisglycinate 100mg
The glycinate chelate form absorbs through a separate intestinal pathway, making it significantly better tolerated and more bioavailable than the magnesium oxide found in most supplements.
Nutrients, Frontiers in Nutrition, PMC6683096
Nutrition
10+
Published studies
Methylcobalamin B12 at 100% RI
The natural, bioactive form of B12 your body uses directly. Research shows it is retained significantly longer in the body than synthetic cyanocobalamin, the cheaper form used in most supplements.
PMC5312744, PMC8311243, Nutrients
What the medication doesn't address.
Digestive disruption
GLP-1 medications slow gastric emptying as part of their mechanism. Nausea, bloating, and discomfort are among the most commonly reported side effects in the early weeks of use.
Cognitive fatigue
The brain runs on glucose and micronutrients. Caloric restriction in the early weeks of adjustment can affect concentration, cognitive performance, and mental clarity.
Lean muscle loss
Rapid weight loss does not distinguish between fat and muscle. Without support, a significant proportion of weight lost on GLP-1 therapy is lean mass.
Electrolyte imbalance
Around 20 percent of daily fluid intake comes from food. When food consumption falls, so does passive hydration, making electrolyte balance harder to maintain.
Micronutrient deficiency
B vitamins, magnesium, zinc, chromium, selenium. All come from food. When intake drops 30 to 60 percent, so does the supply of every micronutrient the body depends on.
Hair and skin thinning
Significant caloric restriction reduces the supply of biotin, zinc, and the amino acids the body uses to maintain hair follicle health, skin integrity, and nail strength. Hair thinning is among the most commonly reported longer-term effects of GLP-1 therapy.
Developed with specialist formulators.
CHAPTER. was not built by generalists. Every ingredient, dose and combination was determined through a rigorous clinical formulation process. One that draws on specialist expertise in metabolic health, clinical nutrition and the specific physiological demands of long-term GLP-1 therapy.
Clinical nutrition
Formulated by specialists with clinical backgrounds in nutritional medicine and micronutrient therapy.
Metabolic health
Deep expertise in how the body regulates weight, energy and hormonal balance. This informs every formulation decision.
GLP-1 therapy
Specific understanding of the side effects, nutrient gaps and physiological changes associated with GLP-1 receptor agonists.
Ingredient science
Each ingredient selected for bioavailability, clinical evidence and compatibility. Never for convenience or cost.
The medication is well-researched. The support around it isn't.
When food intake drops 30 to 60 percent, nutrient intake drops with it. The body's requirements do not.
CHAPTER. was formulated to address that deficit in a single daily serving.
The Formula
CHAPTER.
Daily GLP-1 Support Supplement — 28 active ingredients
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